Hyperbaric oxygen treatment decreases
inflammation and mechanical hypersensitivity in an animal model of inflammatory
pain RSD
Brain Res
vol. 1098, 126 - 128, 2006
Abstract
Background:
Hyperbaric treatment was
initially developed to combat the adverse effects of deep sea diving. In recent
years, hyperbaric oxygen treatment has been used to treat a broad spectrum of
ailments, including delayed-onset muscle soreness, fibromyalgia, and complex
regional pain syndrome (CRPS). However, limited data are available on the
effect of hyperbaric oxygen treatment on inflammatory pain. The effect of
hyperbaric oxygen treatment on carrageenan-induced inflammation and pain in
rats was investigated. It was hypothesized that treatment with hyperbaric
oxygen would decrease paw edema and hyperalgesia in an acute inflammatory pain
model as compared with that of a sham-treated control group.
Methods:
The experiment was conducted
on 44 male Sprague-Dawley rats each between 300 and 350 g. The inflammatory
pain condition was induced by subcutaneous injection of 1% carrageenan
suspended in saline in the left hind paw. Paw volume was assessed via water
displacement with a plethysmometer, and percentage differences were calculated
on the basis of posttreatment measures compared with pretreatment measures.
Hyperalgesia was assessed using the up/down method of mechanical paw withdrawal
thresholds. Hyperbaric oxygen treatment involved exposing animals to 100%
oxygen at a pressure of 2.4 atmospheres absolute (ATA) for 90 minutes in a hyperbaric
chamber. A control group was placed in the hyperbaric chamber but did not
receive treatment.
Results: A 1-way
analysis of variance revealed no significant preinjec-tion group differences.
An overall mixed-design analysis with 2 group levels (treatment, sham) and 7
levels of time revealed a significant main effect for group, a main effect for
time, and a group by time interaction. In the hyperbaric oxygen treatment
group, paw edema remained at pretreatment levels immediately after treatment
and continued to decrease slightly until 2 hours posttreatment, at which time
it began to decrease. However, antinociceptive effects were apparent
immediately after treatment and continued to increase up to 5 hours after
treatment, suggesting that distinct mechanisms might be involved in the
anti-inflammatory and antinociceptive properties of Hyperbaric Oxygen Treatment
.Conclusions: Hyperbaric
oxygen treatment significantly reduced inflammation and pain after carrageenan
injection in this rat model of inflammatory pain. Hyperbaric oxygen may be used
in patients for whom nonsteroidal anti-inflammatory drugs are contraindicated
or for those with persistent inflammation. www,hbot4u.com 909.477.4545
#hbot #RSD #CRPS
#RAPIDRECOVERYHYPERBARICS #OXYGEN #HBOT
www.hbot4u.com 909.477.4545
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